Among the possible issues to examine are your ties to family and friends, the expense of moving and whether or not you're really committed to the craft of screenwriting.
If you've completed a couple of polished scripts, have the financial means to start anew in a strange city and possess the overriding urge to get into the business, the answer is probably yes.
Some folks at Script magazine have tackled the question. They've covered some of the pros and cons, but as a whole, all signs appear to point toward an answer in the affirmative. If you want to make industry contacts and be taken seriously, you're better off facing the long odds in L.A. vs. the nearly impossible odds anywhere else, with the possible exception of New York City. However, bear in mind that New York's film industry is but a fraction of Southern California's.
